Research progress on the mechanism of traditional Chinese medicine intervening in Alzheimer’s disease by microRNA regulation
- VernacularTitle:中药调控微小RNA干预阿尔茨海默病的作用机制研究进展
- Author:
Haoming SONG
1
;
Qiang REN
2
;
Yuanxiang LIU
1
Author Information
1. First Clinical Medical College，Shandong University of Traditional Chinese Medicine，Jinan 250355，China
2. Dept. of Neurology，the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine，Jinan 250355，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
microRNA;
Alzheimer’s disease;
mechanism of action;
β-amyloid protein;
τ protein
- From:
China Pharmacy
2025;36(19):2479-2483
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer’s disease （AD） is mainly characterised by irreversible progressive cognitive dysfunction， which is complex in its pathogenesis and difficult to cure， and seriously affects the quality of life of patients. MicroRNA （miRNA） is a type of small non-coding RNA with high targeting specificity and potential for multi-pathway regulation. This paper takes miRNA as the entry point to systematically elaborate the mechanism of action of traditional Chinese medicine intervening in AD by regulating miRNA. The results revealed that the active ingredients of traditional Chinese medicine （e.g. notoginsenoside R1， salidroside， catalpol， madecassoside， baicalin， dihydromyricetin， osthole， berberine， ursolic acid， parthenolide， thymoquinone， plumbagin）， the extracts of traditional Chinese medicine （e.g.， Ganoderma extract and Ginkgo biloba leaf extract）， and the compound formulas of traditional Chinese medicine （e.g.， Dihuang yinzi decoction， modified Shuyu pill， and Anshen dingzhi formula） can regulate miRNA to reduce the production and deposition of β-amyloid protein， inhibit the over-phosphorylation of τ protein， and inhibit the neuroinflammatory response and programmed neuronal death by regulating miRNA， thus playing a role in intervening in AD.
