Research progress on Astragali Radix for promoting healing of chronic refractory wound
- VernacularTitle:黄芪促进慢性难愈性创面愈合的研究进展
- Author:
Yangyang YU
1
;
Yuan GAO
2
;
Jinling HE
3
;
Hao WU
1
;
Keyu CHEN
1
;
Yuxing ZHAO
1
Author Information
1. Clinical College of Chinese Medicine，Inner Mongolia Medical University，Hohhot 010050，China
2. Clinical College of Chinese Medicine，Inner Mongolia Medical University，Hohhot 010050，China;Colorectal Center，Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine，Hohhot 010050，China
3. Colorectal Center，Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine，Hohhot 010050，China
- Publication Type:Journal Article
- Keywords:
Astragali Radix;
chronic refractory wounds;
basic research;
network pharmacology;
bioinformatics;
clinical
- From:
China Pharmacy
2025;36(19):2473-2478
- CountryChina
- Language:Chinese
-
Abstract:
Chronic refractory wound （CRW） presents significant clinical treatment challenges due to pathological characteristics such as persistent inflammation， bacterial infection， oxidative stress and inadequate angiogenesis. Astragali Radix， a traditional Chinese medicinal herb， exerts multi-target pharmacological effects on CRW through its active components， including Astragalus polysaccharides， flavonoids， and astragaloside Ⅳ， etc. Fundamental studies indicate that these components promote CRW healing by modulating inflammatory responses， inhibiting pathogen growth， improving antioxidant capacity and stimulating neovascularization. Network pharmacology and bioinformatics studies have revealed that active components of Astragali Radix target and modulate key signaling nodes such as nuclear factor-κB， phosphatidylinositol 3-kinase/Akt， AMP-activated protein kinase， and vascular endothelial growth factor receptor， as well as inflammation-angiogenesis-related pathways， thereby synergistically exerting anti-inflammatory and pro-angiogenic effect. Clinical applications have demonstrated that oral formulations （e.g.， Huangqi guizhi decoction， Danggui huangqi decoction， etc.） reduce healing time of CRW and lower inflammatory marker levels， while topical preparations （e.g.， Zizhu ointment， Huangqi shengji ointment， electrostatically spun Astragalus polysaccharide composite nanofibre dressings， etc.） significantly improve healing rates of CRW and minimize complications.
