Clinical practice boundaries and expansion of Landsteiner's rule
10.13303/j.cjbt.issn.1004-549x.2025.09.025
- VernacularTitle:Landsteiner规则的临床实践边界与拓展
- Author:
Yinze ZHANG
1
;
Hua XU
2
;
Huayou ZHOU
3
Author Information
1. Department of Blood Transfusion, Shenzhen University General Hospital, Shenzhen 518955, China
2. Shaanxi Blood Center, Xi'an 710061, China
3. Department of Blood Transfusion, Nanfang Hospital, Guangzhou 510515, China
- Publication Type:Journal Article
- Keywords:
ABO blood group;
Landsteiner's rule;
incomplete inductive reasoning
- From:
Chinese Journal of Blood Transfusion
2025;38(9):1280-1285
- CountryChina
- Language:Chinese
-
Abstract:
Landsteiner established classical rules through incomplete inductive reasoning. Although theoretical incompleteness and application limitations existed due to the limited number of early observation samples, this flaw not only fails to diminish its milestone significance in the history of transfusion medicine, but also vividly illustrates the objective law that scientific cognition possesses historical limitations. Through a systematic review of the research history of ABO blood groups, this study is the first to propose that abnormal phenomena such as weak agglutination, discrepancies between forward and reverse typing, and false concordance are actually inherent reactive characteristics of weak phenotypes. This breakthrough transcends traditional judgment standards and constructs a more universal ABO blood group detection and interpretation model. It not only expands the boundaries of Landsteiner's rules, but also provides practical solutions for clinical laboratories to handle complex samples.
