Traditional Chinese Medicine Regulates Metabolic Reprogramming Mechanism to Intervene in Inflammation-cancer Transformation of Gastric Mucosa
10.13422/j.cnki.syfjx.20250627
- VernacularTitle:中医药调控代谢重编程干预胃黏膜“炎-癌”转化机制
- Author:
Xinyi LIANG
1
;
Jiale MA
2
;
Huizhen LI
2
;
Shuangmei ZHAO
2
;
Mengtong LENG
1
Author Information
1. Tianjin University of Traditional Chinese Medicine（TCM）， Tianjin 301617， China
2. The Second Affiliated Hospital of Tianjin University of TCM， Tianjin 300250， China
- Publication Type:Journal Article
- Keywords:
metabolic reprogramming;
glycolysis;
inflammation-cancer transformation;
pathogenesis;
traditional Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(21):252-260
- CountryChina
- Language:Chinese
-
Abstract:
Gastric cancer （GC） has an insidious onset and is mostly diagnosed in the middle and late stages after clinical detection. It is one of the malignant tumors with high incidence and mortality rates in the world. At present， the treatment plans are optimized mainly in terms of surgery， radiotherapy， and intervention， while the endpoints of clinical trials， such as patients' overall survival， progression-free survival， and disease-free survival， are still unsatisfactory. Therefore， effectively delaying the dynamic inflammation-cancer transformation has become an urgent bottleneck in the prevention and treatment of GC. In 1920s， Professor Otto Warburg discovered the phenomenon that tumor cells can accelerate glycolysis. Since then， the abnormal metabolic network inside tumor cells has gradually entered into researchers' view， and the hot academic research topic of metabolic reprogramming has been proposed. Tumor cells can meet their own energy consumption and adapt to external changes by adjusting their metabolic pathways to achieve rapid proliferation. In recent years， traditional Chinese medicine （TCM） is resolutely pursuing innovation in inheritance and the continuous refinement of research has led to the precision-oriented transition of TCM theories. Therefore， linking TCM with the treatment of tumors and precancerous diseases has certain research connotations. The searching and review of the publications in this field revealed that the number of publications in tumor-related metabolism increased dramatically， while there were only a few studies using TCM as a therapeutic solution. The research group has long been committed to the study of precancerous lesions of gastric cancer （PLGC） in Chinese and Western medicine. This article explained the dynamic process of inflammation-cancer transformation from the perspective of spleen deficiency-Qi stagnation-collateral stasis. The molecules of hypoxia-inducible factor （HIF）-1α， cancer-Myc （c-Myc）， apolipoprotein E （APOE） and pyruvate kinase M2 （PKM2） were selected to reflect the biological connotation of inflammation-cancer transformation. The current achievements of TCM in regulating the metabolic reprogramming to intervene in inflammation-cancer transformation were summarized， with a view to providing more information for TCM to intervene in the inflammation-cancer transformation of gastric mucosa.
