Establishment and Application of Animal Models for Disease-syndrome Combination in Viral Pneumonia： A Review
10.13422/j.cnki.syfjx.20251243
- VernacularTitle:呼吸道病毒感染肺炎病证结合动物模型构建及应用的研究进展
- Author:
Dan XIE
1
;
Shuran LI
1
;
Zihan GENG
1
;
Lei BAO
1
;
Jing SUN
1
;
Ronghua ZHAO
1
;
Xian LIU
1
;
Mengyao CUI
1
;
Xiaowei YANG
1
;
Xiaolan CUI
1
;
Shanshan GUO
1
Author Information
1. Institute of Chinese Materia Medica， China Academy of Chinese Medical Sciences， Beijing 100700， China
- Publication Type:Journal Article
- Keywords:
viral pneumonia;
disease-syndrome combination;
animal model;
traditional Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(21):61-69
- CountryChina
- Language:Chinese
-
Abstract:
Currently， viral pneumonia （VP） presents a major challenge to global public health. Traditional Chinese medicine （TCM） prevention and treatment of VP is guided by the core concept of strengthening vital energy and eliminating pathogenic factors rather than targeting specific pathogens， alongside a holistic approach of syndrome differentiation and treatment. By summarizing the clinical syndromes of patients， the core pathogenesis was clarified to achieve individualized therapy. Animal models for disease-syndrome combination integrate the etiology and pathogenesis of VP and simulate the individualized manifestations of patients at different disease stages， providing an experimental platform for elucidating the theoretical basis of TCM in treating VP and promoting the development of effective TCM formulations. However， there are limitations in the application and promotion of disease-syndrome combination animal models due to the lack of standardization and normalization of model construction systems， which arise from diverse species selection， compound modeling methods， and multidimensional evaluation indicators. This paper systematically reviewed the recent research on animal models for disease-syndrome combination in VP from the perspective of species selection， modeling methods， evaluation indicators， and application status. Furthermore， it summarized the advantages and limitations of existing models， identifies future directions for improvement， and proposes optimization strategies. This review provides a reference for establishing standardized and normalized animal models for disease-syndrome combinations in VP， supporting the theoretical modernization of TCM in preventing and controlling emerging respiratory infectious diseases， and contributing to the development of new TCM drugs.
