Case analysis on sequential latent occupational acute organotin poisoning
10.20001/j.issn.2095-2619.20250612
- VernacularTitle:序贯隐匿性职业性急性有机锡中毒患者分析
- Author:
Lizhuang LU
1
;
Linlin FAN
;
Yinghua SONG
;
Jia LIU
;
Yongjian YAN
Author Information
1. Respiratory Disease Diagnosis and Treatment Center/ Toxicity and Occupational Diseases Department, Shandong Provincial Second People's Hospital, Jinan, Shandong 250021, China
- Publication Type:Journal Article
- Keywords:
Latent poisoning;
Organotin;
Trialkyltin;
Occupational hazards;
Hypokalemia;
Sequential
- From:
China Occupational Medicine
2025;52(3):308-312
- CountryChina
- Language:Chinese
-
Abstract:
A retrospective investigation was conducted to analyze the occupational exposure history, clinical manifestations, laboratory tests, imaging findings, and diagnosis and treatment of two cases of sequential latent occupational acute organotin poisoning. Both patients were successively employed in the same enterprise, engaged in crushing of waste polyvinyl chloride plastics, and thus potentially exposed to organotin hazards. Within several days of employment, both patients developed discomfort symptoms, and central nervous system impairment was observed, including short-term memory loss, slow response, and cognitive dysfunction. Hypokalemia was detected in both cases. Cranial magnetic resonance imaging showed abnormalities (multiple ischemic lesions in the bilateral frontal and parietal lobes), and urinary tin was positive. Symptoms relieved in both patients after treatments with tin-exclusion, potassium supplementation, and neurotrophic treatment. Based on the GBZ 26-2007 Diagnostic Criteria of Occupational Acute Trialkyltin Poisoning, and combined with worksite survey of occupational health and exclusion of cerebrovascular disease, viral encephalitis, and autoimmune encephalitis and other neurological disorders, both patients were diagnosed with mild occupational acute trialkyltin poisoning. Sequential latent occupational acute organotin poisoning is prone to misdiagnosis, with great difficulty in etiological identification. Comprehensive assessment of occupational exposure history and biomarker testing are essential for differential diagnosis. Early recognition and intervention improve prognosis, highlighting the need for strengthened occupational health supervision and protection in high-risk work posts.
