Association between dysbiosis of the gut and lung microbiome and asthma in children
10.3969/j.issn.1006-2483.2025.05.028
- VernacularTitle:儿童肠道和肺微生物组的生态失调与哮喘的相关性调查
- Author:
Peng TONG
1
;
Menghua CHENG
1
;
Yingchun WANG
1
;
Shuping ZHOU
2
;
Youdong YAO
3
Author Information
1. Pediatric Department of Ezhou Central Hospital , Ezhou , Hubei 436000 , China
2. Department of Pediatrics , Ezhou Maternal and Child Health Hospital , Ezhou , Hubei 436000 , China
3. Department of Pediatrics , Egang Hospital , Ezhou , Hubei 436000 , China
- Publication Type:Journal Article
- Keywords:
Children;
Asthma;
Microbe
- From:
Journal of Public Health and Preventive Medicine
2025;36(5):125-129
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the types and distribution of microbiome in intestinal and lung tissues of children with asthma, and to explore the correlation between microbiota changes and asthma. Methods From 2021 to 2023, a total of 28,939 children with asthma who visited Ezhou Central Hospital, Maternal and Child Health Hospital or Ezhou Egang Hospital were selected as the study subjects, and 2,000 healthy children who underwent outpatient physical examinations at these three hospitals during the same period were selected as the control group. The distribution and characteristics of intestinal and pulmonary microbiome in the two groups were analyzed by 16SrDNA sequencing. Logistic regression analysis model was used to analyze the correlation between microbiota distribution and asthma occurrence. Results In the intestinal tissues of children with asthma compared to healthy children, the abundance of Bacteroidetes at the phylum level decreased, while the abundance of Firmicutes and Proteobacteria increased significantly (P<0.05), and the abundance of Prevotalle and Clostridium at the genus level increased significantly. In lung tissues of asthmatic children compared to health children, the abundance of Firmicutes at the phylum level decreased while the abundance of Proteobacteria increased significantly (P<0.05), and the abundance of Neisseria, Prevotella and Actinomyces at the genus level increased significantly. Binary logistic regression results showed that the abundances of Lactobacillus (OR=0.842, 95% CI: 0.533-0.947), Bacteroides fragilis (OR=0.649, 95%CI: 0.377-0.890), Bifidobacterium (OR=0.901, 95% CI: 0.633-0.994), and Parabacteroides distasonis (OR=0.547, 95% CI: 0.192-0.708) in the intestinal tissues were all protective factors for the asthma in children. In the lung tissue, the abundance of Neisseria (OR=2.140, 95% CI: 1.749-3.305) was a risk factor for the asthma in children, and Prevotella (OR=0.691, 95% CI: 0.491-0.926) was a protective factor for the asthma in children (P<0.05). Conclusion The dysbiosis of intestinal and pulmonary microbiome is closely related to the occurrence of asthma in children, and the detection of microbiota is of great significance for the diagnosis of childhood asthma.
