Correlation between ICAM-1, CD62P, and inflammatory factors and cerebral artery stenosis in patients with acute cerebral infarction
10.3969/j.issn.1006-2483.2025.05.020
- VernacularTitle:急性脑梗死患者ICAM-1 , CD62P及炎症因子与脑动脉狭窄的相关性分析
- Author:
Yunying WU
1
;
Tao HAN
2
;
Yanbo CHENG
3
;
Qian ZHAO
4
Author Information
1. Department of Neurology , Affiliated Hospital of Xuzhou Medical University , Xuzhou, Jiangsu 221004 , China;Department of Critical Care Medicine , Suqian Zhongwu Hospital , Suqian , Jiangsu 223800 , China
2. Department of Critical Care Medicine , Suqian Zhongwu Hospital , Suqian , Jiangsu 223800 , China
3. Department of Neurology , Affiliated Hospital of Xuzhou Medical University , Xuzhou, Jiangsu 221004 , China
4. Department of Neurology , Xinyi People's Hospital , Xuzhou , Jiangsu 221400 , China
- Publication Type:Journal Article
- Keywords:
Acute cerebral infarction;
Intercellular adhesion molecule-1;
Platelet surface P-selectin;
Inflammatory factors;
Cerebral artery stenosis
- From:
Journal of Public Health and Preventive Medicine
2025;36(5):89-92
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between levels of intercellular adhesion molecule-1 (ICAM-1), platelet surface P-selectin (CD62P), and inflammatory factors and cerebral artery stenosis in patients with acute cerebral infarction (ACI). Methods A total of 305 patients with ACI complicated with cerebral artery stenosis admitted to Zhongwu Hospital of Suqian City and Xinyi People's Hospital from January 2021 to December 2023 were selected as the research subjects. According to the degree of cerebral artery stenosis, they were divided into grade I group (stenosis degree<50%, n=85), grade II group (stenosis degree of 50%-75%, n=128), and grade III group (stenosis degree>75%, n=92). Sixty-eight ACI patients without cerebral artery stenosis during the same period were included in the reference group. The levels of serum inflammatory factors [C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-8 (IL-8)], ICAM-1 and CD62P were compared among the four groups. Spearman analysis was used to analyze the correlation between each factor and degree of cerebral artery stenosis. Results The levels of CRP, TNF-α, IL-6, IL-8, ICAM-1 and CD62P in the grade I, II and III groups were higher than those in the reference group. The levels of these factors were higher in the grade II and III groups than those in the grade I group, while the levels of various factors were higher in the grade III group than those in the grade II group (P<0.05). Spearman analysis showed that CRP, TNF-α, IL-6, IL-8, ICAM-1, and CD62P were positively correlated with the degree of cerebral artery stenosis in patients with ACI complicated with cerebral artery stenosis (P<0.05). Conclusion The levels of serum inflammatory factors, ICAM-1 and CD62P are significantly correlated with cerebral artery stenosis degree in patients with ACI.
