Relationship between plasma atherosclerosis index and its cumulative exposure and stroke risk in middle-aged and elderly people
10.3969/j.issn.1006-2483.2025.05.002
- VernacularTitle:血浆动脉粥样硬化指数及其累积暴露与中老年人脑卒中风险研究
- Author:
Meishan CHEN
1
;
Jun ZHANG
2
Author Information
1. School of Nursing , Wuhan University , Wuhan , Hubei 430071 , China
2. The Second Xiangya Hospital , Central South University , Changsha , Hunan 410011, China
- Publication Type:Journal Article
- Keywords:
Atherogenic index of plasma;
Stroke;
Middle-aged and elderly population;
Risk prediction;
Cohort studies
- From:
Journal of Public Health and Preventive Medicine
2025;36(5):8-12
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between baseline and cumulative plasma atherosclerotic index (AIP) and new-onset stroke in the middle-aged and elderly population, and to provide a basis for early screening and prevention of stroke. Methods This study was based on data from the China Health and Retirement Longitudinal Study (CHARLS) and included middle-aged and elderly people who participated in four surveys in 2011, 2015, 2018 and 2020. Restricted cubic spline (RCS) model was used to analyze the dose-response relationship between AIP and stroke risk. Cox proportional risk regression model was used to assess the effects of baseline AIP and cumulative AIP levels on stroke risk. Results A total of 551 (6.54%) new stroke events were recorded during the 9-year follow-up period. The results showed an increasing trend in the risk of stroke in the middle-aged and elderly population with increasing baseline AIP levels. In the baseline AIP quartile subgroups, the risk of stroke increased by 33%, 60%, and 61% in the Quartile 2, Quartile 3, and Quartile 4 groups, respectively, compared with the lowest quartile group (Quartile 1), with HRs and 95% CIs of 1.33 (1.03-1.74), 1.60 (1.24-2.07) and 1.61 (1.23-2.08), respectively. In the quartile subgroups with cumulative AIP, a 39% increased risk of stroke was observed only in the highest quartile group (Quartile 4) compared with the lowest quartile group (Quartile 1) (HR=1.39, 95% CI: 1.03-1.88). Conclusion Elevated baseline AIP and cumulative AIP levels are generally associated with an increased risk of stroke.
