Persistent HPV Infection Among Women in Zhengzhou, China: A Prevalence Study
10.3971/j.issn.1000-8578.2025.25.0162
- VernacularTitle:郑州地区女性宫颈HPV持续感染的流行病学研究
- Author:
Haixia DUAN
1
;
Jin QIAN
1
;
Yao ZHANG
1
;
Zhimin REN
1
;
Guohong ZHAO
1
;
Junyan HONG
2
;
Xinmin LI
1
Author Information
1. Department of Pathology, Women and Infants Hospital of Zhengzhou, Zhengzhou 450012, China;Key Laboratory of Cervical Cancer Prevention and Control in He'nan Province, Zhengzhou 450012, China.
2. Key Laboratory of Cervical Cancer Prevention and Control in He'nan Province, Zhengzhou 450012, China.
- Publication Type:EPIDEMIOLOGY
- Keywords:
High-risk human papillomavirus;
Persistent HPV infection;
Cervical cancer;
Cervical intraepithelial lesions
- From:
Cancer Research on Prevention and Treatment
2025;52(9):770-775
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the status of persistent human papillomavirus (HPV) infection and the distribution of viral subtypes in the Zhengzhou region. Methods Clinical data of 55239 patients who underwent HPV-DNA genotyping tests from 2018 to 2024 were collected. On the basis of HPV follow-up results, patients were divided into three groups: 849 cases of infection with the same HPV type, 255 cases of persistent infection with different HPV types, and 857 cases of transient HPV infection. Results Among the 9232 initially-screened patients who were positive with HPV, the high-risk HPV (HR-HPV) positive rate was 84.6% (7813/9232), and predominant subtypes were HPV-16 (20.8%), HPV-52 (17.2%), and HPV-53 (9.6%). The low-risk HPV (LR-HPV) positive rate was 15.4% (1419/9232), mainly HPV-81 (28.1%) and HPV-42 (27.0%). Among the 1961 follow-up cases, the rates of persistent and non-persistent infections with the same HPV type were 35.7% (701/1961) and 7.5% (148/1961), respectively. The rates of persistent and non-persistent infections with different HPV types were 10.9% (214/1961) and 2.1% (41/1961), respectively. Meanwhile, 43.7% (857/1961) tested negative upon follow-up. Among the 701 cases of persistent infection with the same HPV type, HR-HPV accounted for 85.7% (601/701), and LR-HPV accounted for 14.3% (100/701). Among the 214 cases of persistent infection with different HPV types, 89.7% (192/214) were high-risk transitions, and 10.3% (22/214) were low-risk transitions. Regardless of HPV types, HR-HPV was more likely to cause persistent infection than LR-HPV. In addition, over 60% of HR-HPV persistent infections resolved within 18 months, 30% developed into persistent infections, and only 15% of patients had persistent infections that last more than 24 months. Conclusion Persistent HPV infections are predominantly high-risk types. Most patients clear the infection within 18 months, approximately 30% develop persistent infections, and about 15% of patients have persistent infections that last more than 24 months. However, the HR-HPV persistent infection rates across different age groups slightly differ.
