Research progress on the mechanism of traditional Chinese medicine monomers acting on myelosuppression after chemotherapy based on the four properties theory
- VernacularTitle:基于四气理论的中药单体对化疗致骨髓抑制的作用机制研究进展
- Author:
Sihan ZHANG
1
;
Tingting WANG
2
;
Zhifen ZHAO
3
;
Hanyu KANG
1
;
Jiaqi JI
1
;
Ziqiang GUO
1
;
Tong LIU
1
;
Shiqing JIANG
4
Author Information
1. Dept. of Hematology and Oncology，the First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003，China;First Clinical Medical College，Henan University of Chinese Medicine，Zhengzhou 450046，China
2. Dept. of Emergency，the First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003，China
3. Pediatric Hospital，the First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003，China
4. Dept. of Hematology and Oncology，the First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine monomers;
four properties theory;
myelosuppression;
chemotherapy;
mechanism of
- From:
China Pharmacy
2025;36(18):2341-2347
- CountryChina
- Language:Chinese
-
Abstract:
Chemotherapy is an important treatment for tumors， but most patients experience varying degrees of chemotherapy- induced myelosuppression. Four properties theory of traditional Chinese medicine （TCM） has unique advantages in improving chemotherapy-induced myelosuppression. The monomers from TCM with different properties and flavors， such as cold-natured （e.g. Scutellaria baicalensis， Rhus chinensis）， cool-natured （e.g. Ligustrum lucidum， Ophiopogon japonicus）， warm-natured （e.g. Panax ginseng， Epimedium brevicornu， Curcuma longa， Angelica sinensis）， hot-natured （e.g. Cinnamomum cassia， Aconitum carmichaeli）， and neutral-natured （e. g. donkey-hide gelatin， Lycium barbarum， Rhodiola rosea， fungi）， can exert anti- myelosuppressive effects by reducing damage to hematopoietic stem/progenitor cells， improving the bone marrow hematopoietic microenvironment， inhibiting the oxidative stress response， regulating signaling pathways， so as to ultimately repaire inflammatory damage and improve hematopoietic function， thereby playing an anti-myelosuppressive role.
