Application of indocyanine green combined with autologous blood and methylene blue in localizing pulmonary nodules in lung wedge resection
- VernacularTitle:吲哚菁绿联合自体血和亚甲蓝定位肺小结节在肺楔形切除中的应用
- Author:
Zijie WANG
1
;
Zhi FENG
2
,
3
;
Min LIN
2
,
3
;
Yuanrong TU
2
,
3
;
Quan DU
2
,
3
;
Jianfeng CHEN
2
,
3
Author Information
1. The First Clinical Medical College of Fujian Medical University, Fuzhou, 350122, P. R. China
2. Department of Thoracic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, P. R. China
3. Department of Thoracic Surgery, The First Affiliated Hospital of Fujian Medical University (Binhai Campus), National Regional Medical Center, Fuzhou, 350212, P. R. China
- Publication Type:Journal Article
- Keywords:
Pulmonary nodule;
indocyanine green;
nodule localization;
lung wedge resection
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2025;32(06):792-797
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the feasibility and safety of using indocyanine green combined with autologous blood and methylene blue for localization of small lung nodules during thoracoscopic wedge resection. Methods Patients who underwent CT-guided percutaneous lung puncture injection of localization agents to locate lung nodules at the First Affiliated Hospital of Fujian Medical University from November 2023 to January 2024 were selected. Under thoracoscopy, lung nodules were located by white light mode, fluorescence mode, or near-infrared mode and wedge resection was performed. The feasibility of using indocyanine green combined with autologous blood and methylene blue for localization of small lung nodules was preliminarily verified by evaluating whether the localization agent concentrated around the nodules, and the safety of this method was verified by analyzing the incidence of adverse reactions during patient puncture and surgery. Results A total of 30 patients with lung nodules were included, including 10 males and 20 females, with an average age of (55.5±11.2) years. In 26 patients, the amount of localization agent used was moderate, the localization agent concentrated around the nodules, and successful precise localization of small lung nodules was achieved. In 4 patients, due to excessive use of localization agent, the marker was diffuse with pleural staining. The overall localization success rate was 86.7%, and when the injection volume of localization agent was 0.2-0.5 mL, the localization success rate was 100.0%. All patients successfully completed thoracoscopic wedge resection and found nodule lesions, with negative margins and a distance from the margin to the lesion that met the requirements. There were no complications. Conclusion Thoracoscopic surgery using indocyanine green combined with autologous blood and methylene blue for localization of small lung nodules is safe and feasible.
