Research advances in in vitro cellular models for age-related macular degeneration
10.3980/j.issn.1672-5123.2025.9.13
- VernacularTitle:年龄相关性黄斑变性体外细胞模型的研究进展
- Author:
Xin CHEN
1
;
Yaxin MO
1
;
Xinyu LIU
1
;
Qiang CHEN
1
Author Information
1. Eye Hospital China Academy of Chinese Medical Sciences, Beijing 100040, China
- Publication Type:Journal Article
- Keywords:
age-related macular degeneration;
in vitro cellular model;
model construction
- From:
International Eye Science
2025;25(9):1460-1465
- CountryChina
- Language:Chinese
-
Abstract:
Age-related macular degeneration(ARMD)is a leading cause of irreversible vision loss in the elderly, characterized by complex mechanisms such as oxidative stress, inflammation, and metabolic dysregulation. In vitro cellular models have become indispensable in ARMD research, enabling the study of ARMD pathogenesis, drug screening, and treatment evaluation through retinal microenvironment simulation. This review provides a systematic overview of recent advances in various in vitro models for ARMD research, encompassing retinal pigment epithelium(RPE)cell cultures, 3D bioprinted retinal constructs, and organoid technologies. We critically examine their development methodologies, experimental applications, as well as comparative strengths and weaknesses. The review also addresses ongoing debates and technical challenges in this research domain. In the future, continued progress in microfluidic platforms, gene-editing tools, and 3D bioprinting technologies promises to enhance the precision and patient-specific relevance of these models, ultimately facilitating earlier diagnosis and more tailored therapeutic interventions for ARMD.
