Research progress on the treatment role and chemical synthesis methods of isoselenoazolones
10.12206/j.issn.2097-2024.202308064
- VernacularTitle:异硒唑酮类化合物在疾病治疗中的作用和化学合成方法
- Author:
Wentao WANG
1
;
Xing GAO
1
;
Fengping ZHAO
1
;
Canhui ZHENG
2
;
Xin CHEN
3
Author Information
1. School of Life Science and Technology,Wuhan Polytechnic University, Wuhan 430023，China;School of Pharmacy, Naval Medical University, Shanghai 200433，China.
2. School of Pharmacy, Naval Medical University, Shanghai 200433，China.
3. School of Life Science and Technology,Wuhan Polytechnic University, Wuhan 430023，China.
- Publication Type:Reviews
- Keywords:
organoselenium compounds;
isoselenoazolones;
ebselen;
glutathione peroxidase;
mimics
- From:
Journal of Pharmaceutical Practice and Service
2025;43(8):367-372
- CountryChina
- Language:Chinese
-
Abstract:
Glutathione peroxidase （GSH-Px） is a key selenoenzyme that protects the body from oxidative damage. A series of small molecular organic selenium compounds have been designed and synthesized as functional mimics of GPx, among which isoselenazolones are the most widely studied. Taking ebselen as a representative, the catalytic mechanism of isoselenazolones in mimicing GSH-Px activity in vivo, the therapeutic effects of isoselenazolones in stroke, sensorineurium deafness and tinnitus, treatmentresistant depression （TRD） and coronavirus disease 2019 （COVID-19）, and research on their chemical synthesis methods were summarized and discussed in this paper.
