Regulation of Oxidative Stress by Traditional Chinese Medicine in Prevention and Treatment of Myocardial Ischemia-reperfusion Injury： A Review
10.13422/j.cnki.syfjx.20250701
- VernacularTitle:中药调节氧化应激防治心肌缺血再灌注损伤的研究进展
- Author:
Haosen ZHAO
1
;
Weijie REN
1
;
Jiahao LI
1
;
Peili WANG
2
Author Information
1. Shanxi University of Chinese Medicine，Jinzhong 030619，China
2. Affiliated Hospital of Shanxi University of Chinese Medicine，Taiyuan 030024，China
- Publication Type:Review
- Keywords:
oxidative stress;
myocardial ischemia-reperfusion injury;
traditional Chinese medicine;
signaling pathway;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(18):268-276
- CountryChina
- Language:Chinese
-
Abstract:
Myocardial ischemia-reperfusion injury （MIRI） is a major complication following coronary revascularization. Studies indicate that its pathophysiological mechanisms of MIRI are closely associated with oxidative stress， iron overload， inflammatory responses， and lipid peroxidation. Oxidative stress refers to an imbalance in redox homeostasis under pathological conditions， characterized by the abnormal accumulation of reactive oxygen species （ROS）， which disrupts the dynamic balance between pro-oxidant systems and antioxidant defense networks. In recent years， traditional Chinese medicine （TCM） has demonstrated unique advantages in the prevention and treatment of MIRI due to its multi-target and multi-pathway antioxidant properties. Research reveals that TCM primarily exerts protective effects against oxidative stress-induced MIRI by regulating signaling pathways such as nuclear factor erythroid 2-related factor 2 （Nrf2）， adenosine monophosphate-activated protein kinase （AMPK）， phosphatidylinositol 3-kinase/protein kinase B （PI3K/Akt）， nuclear factor kappa-B （NF-κB）， Janus kinase 2/signal transducer and activator of transcription 3 （JAK2/STAT3）， and protein kinase C beta Ⅱ/nicotinamide adenine dinucleotide phosphate oxidase 2/reactive oxygen species （PKCβⅡ/NOX2/ROS）. This article reviews recent literature on TCM monomers， compound formulas， and their active components， which alleviate oxidative stress to prevent and treat MIRI by modulating the aforementioned signaling pathways. It summarizes a concise overview of the molecular mechanisms by which oxidative stress-related signaling pathways lead to MIRI， discusses how TCM regulates these pathways to reduce oxidative stress-induced MIRI， and explores clinical application prospects and research challenges， aiming to provide a theoretical reference for the research and clinical management of MIRI.
