Reflections on Research and Development of New Tibetan Medicines Based on Ancient Famous Classical Formulas
10.13422/j.cnki.syfjx.20251568
- VernacularTitle:关于古代经典名方藏药新药研发的思考
- Author:
Siyi LIU
1
;
Xiu XIANG
2
;
Wei HAN
1
Author Information
1. Center for Drug Evaluation，National Medical Products Administration，Beijing 100076，China
2. Tibetan Medicine Evaluation and Certification Center， Tibet Autonomous Region Medical Products Administration，Lhasa 850000，China
- Publication Type:Journal Article
- Keywords:
Tibetan medicine;
catalogue of ancient famous classical formulas;
compound preparations;
new drug research and development;
new drug registration;
traditional medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(18):261-267
- CountryChina
- Language:Chinese
-
Abstract:
With the increasing attention paid by the state to traditional medicine and the need for the inheritance and innovative development of Tibetan medicine in the new era， the research and development of new Tibetan medicines has attracted the attention of the industry. This article analyzes the characteristics of prescriptions， dosage forms， preparation methods， and processing of the 34 Tibetan medicine formulas included in the Catalogue of Ancient Famous Classical Formulas（Second Batch）， discusses the problems and challenges in the research and development of ancient famous classical formulas of Tibetan medicine， and puts forward opinions and suggestions in order to promote the research and development of new Tibetan medicine. The main issues that may be encountered in the research and development of 34 Tibetan medicine formulas are as follows：①Some medicinal material resources are scarce， and planting/breeding technologies are not yet mature. Among the 34 formulas， there are not only ingredients derived from endangered protected animals， but also national second-class protected plants and rare high-altitude wild species. ②The quality control level of Tibetan medicinal materials urgently needs to be strengthened and improved. After review， among the 102 medicinal materials in the 34 Tibetan medicine formulas， there are 2 varieties that currently have no national or local medicinal material standards/decoction piece processing specifications. Excluding those without quality standards， the proportion of varieties without any quantitative testing items is 49%. ③There are a large number of mineral medicines in Tibetan medicine formulas， making quality control difficult. The proportion of formulas containing mineral medicines among the 34 formulas is 35%， and most of them have not yet established a targeted quality standard system. ④Some Tibetan medicinal materials in the 34 formulas have unclear origins， with issues such as different substances with the same name and the same substance with different names. ⑤The 34 formulas contain medicinal materials labeled as toxic or slightly toxic in the current quality standards. It is recommended to accelerate the verification of key information of Tibetan medicine， and on this basis， to intensify research on planting and breeding， quality control in response to the above issues. It is also suggested to encourage the rational use of new technologies and processes that are suitable for the characteristics of preparations to develop new drugs from ancient famous classical formulas of Tibetan medicine， and promote the inheritance and innovative development of Tibetan medicine.
