Research progress on the mechanism of metformin in the intervention of cognitive impairment-related diseases
- VernacularTitle:二甲双胍干预认知障碍相关疾病的作用机制研究进展
- Author:
Yuan LIU
1
;
Yumin XU
2
;
Shiyu LIU
1
;
Huayu YAN
1
;
Xin YANG
1
;
Hongcai XU
1
;
Yabo WU
3
Author Information
1. Dept. of Encephalopathy，the First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003，China;The First Clinical Medical College，Henan University of Chinese Medicine，Zhengzhou 450046，China
2. Dept. of Encephalopathy，the First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003，China;The First Clinical Medical College，Henan University of Chinese Medicine，Zhengzhou 450046，China;Henan Province Collaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine，Zhengzhou 450046，China
3. Dept. of Encephalopathy，the First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003，China
- Publication Type:Journal Article
- Keywords:
metformin;
cognitive impairment;
Alzheimer’s disease;
diabetes cognitive impairment;
pharmacological action
- From:
China Pharmacy
2025;36(15):1942-1946
- CountryChina
- Language:Chinese
-
Abstract:
Cognitive impairment （CI） is a clinical syndrome characterized by progressive decline in advanced cognitive functions such as memory， thinking， and judgment. Its etiology and pathogenesis are complex， and there is currently a lack of specific drug interventions. Metformin， as a first-line hypoglycemic drug for type 2 diabetes， not only lowers blood glucose levels but also improves CI. This article reviews and summarizes the pharmacological effects and mechanisms of metformin in improving Alzheimer’s disease， diabetes cognitive impairment， cognitive impairment after chemotherapy， in order to provide novel insights and approaches for the treatment of CI-related diseases. Studies have shown that the mechanism by which MET intervenes in CI mainly includes regulating β-amyloid protein and tau protein metabolism， reducing insulin resistance， inhibiting neuroinflammation， improving synaptic plasticity， improving mitochondrial dysfunction， regulating gut microbiota and lipid metabolism， etc. Future research needs to be conducted through interdisciplinary collaboration， fully integrating multiple omics data， and combining advanced technologies to further reveal their mechanisms of effect.
