Research progress on periodontal pathogen inducing mitochondrial dysfunction promoting periodontitis
10.12016/j.issn.2096-1456.202550037
- Author:
LI Limin
1
;
PENG Xian
2
;
ZHOU Xuedong
1
Author Information
1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University
2. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Dis-eases & West China Hospital of Stomatology, Sichuan University
- Publication Type:Review
- Keywords:
mitochondria;
periodontitis;
periodontal pathogen;
mitochondrial dysfunction;
mitochondrial biogenesis;
mitochondrial dynamics;
mitophagy
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2025;33(9):801-808
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondria, ubiquitous energy-producing organelles in eukaryotic cells, can have their normal functions disrupted by bacterial infections, leading to mitochondrial dysfunction. This dysfunction is closely associated with inflammatory diseases. Periodontitis, a chronic inflammatory disorder of periodontal tissues caused by pathogenic microorganisms, has been increasingly linked to mitochondrial dysfunction in its pathogenesis and progression. Compared to healthy periodontal tissues, inflammatory lesions exhibit more pronounced mitochondrial dysfunction—a pathological process that is strongly correlated with periodontal pathogen infection. Studies reveal that these pathogens disrupt mitochondrial homeostasis in host cells (e.g., gingival epithelial cells and fibroblasts) through multiple mechanisms, including disrupting mitochondrial biogenesis, altering mitochondrial dynamics (promoting excessive fission), inhibiting mitophagy, impairing mitochondrial dysfunction-associated apoptosis, and inducing endogenous oxidative stress, which upregulates pro-inflammatory cytokines. Collectively, these processes drive the establishment and persistence of an inflammatory microenvironment. This review explores how periodontal pathogens affect mitochondrial function and their mechanistic contributions to periodontitis progression, with the goal of providing novel insights for developing mitochondria-targeted therapeutic strategies.
- Full text:2025090514381629289牙周致病菌诱导线粒体功能障碍促进牙周炎的研究进展.pdf
