Disease-modifying treatment for post-stroke epilepsy
10.19845/j.cnki.zfysjjbzz.2025.0132
- VernacularTitle:卒中后癫痫的疾病修饰治疗
- Author:
Xinwei LI
1
;
Qun WANG
2
Author Information
1. 郑州大学第一附属医院神经内科，河南 郑州 450000
2. 郑州大学第一附属医院神经内科，河南 郑州 450000;首都医科大学附属北京天坛医院神经病学中心， 北京 100070;国家神经系统疾病临床医学研究中心，北京 100070
- Publication Type:Journal Article
- Keywords:
Post-stroke seizure;
Post-stroke epilepsy;
Mechanism research;
Disease-modifying treatment
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(8):685-692
- CountryChina
- Language:Chinese
-
Abstract:
Post-stroke epilepsy （PSE） is one of the most common complications of stroke and represents a leading cause of secondary epilepsy in adults. Its development follows a well-defined temporal sequence， progressing through stroke onset， latent phase remodeling， and eventual seizure manifestation. PSE is classified into early- and late-onset types based on the timing of seizures. The former is associated with acute injury， while the latter involves chronic reorganization of neural networks. During the latent phase， the brain exhibits pathological changes such as disrupted synaptic plasticity， inflammatory activation， oxidative stress accumulation， and blood-brain barrier disruption， offering a critical window for therapeutic intervention. However， conventional antiseizure medications， which primarily inhibit abnormal neuronal discharges， are insufficient to reverse the underlying pathogenesis and show limited preventive efficacy. Against this backdrop， the concept of disease-modifying treatment （DMT） has gained traction. DMT underscores mechanistic， targeted， and early-stage interventions that prioritize core processes such as inflammation， synaptic remodeling， ferroptosis， and miRNA regulation. Due to its predictability and ease of modeling， PSE serves as an ideal platform for DMT research. Emerging strategies encompass small-molecule drugs， stem cell transplantation， epigenetic modulation， and neuromodulation， some of which have shown promising results in animal models. This review systematically summarizes the pathogenesis of PSE and recent advances in DMT approaches， providing a theoretical foundation and practical guidance for clinical interventions.
- Full text:2025090409294419999卒中后癫痫的疾病修饰治疗.pdf
