Clinical features and prognosis of adult brain abscess： A 12-year single-center retrospective analysis of 173 cases
10.19845/j.cnki.zfysjjbzz.2025.0123
- VernacularTitle:成人脑脓肿临床特点及预后：单中心12年173例患者回顾性分析
- Author:
Wen LI
1
Author Information
1. Department of Neurology， Xijing Hosiptal， Air Force Medical University， Xi’an 710032， China
- Publication Type:Journal Article
- Keywords:
Brain abscess;
Prognosis;
Risk factors;
Prediction
- MeSH:
Prognosis
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(7):641-645
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prognosis of patients with brain abscess and related influencing factors. Methods A retrospective analysis was conducted for the patients with brain abscess who were consecutively admitted to Department of Neurology， Xijing Hospital of Air Force Medical University， from January 2010 to March 2022， and according to the Glasgow Outcome Scale（GOS） score at discharge， the patients were divided into good prognosis group （GOS score>3 points） and poor prognosis group（GOS score≤3 points）. The t-test， the Wilcoxon rank-sum test， the chi-square test， and the Logistic regression analysis were used to investigate the influencing factors for prognosis. Results Among the 173 patients with brain abscess，69（39.9%） had a poor prognosis， and 104 （60.1%） had a good prognosis. There were significant differences between the two groups in age， headache， seizure， coma events， focal neurological deficits， dexamethasone treatment， and cerebellar abscess （P<0.05）.The multivariate logistic regression analysis showed that age （OR=0.042，95%CI 1.001‒1.041，P=0.042）， seizure（OR=2.881，95%CI 1.172‒7.083，P=0.021）， and coma events （OR=2.694， 95%CI 1.195‒6.072， P=0.017） were significant predictive factors for poor prognosis. Conclusion Age， seizure， and coma events are major factors associated with poor prognosis. Age is an uncontrollable factor， and therefore， timely prevention and management of seizure and coma events can reduce the incidence rate of poor prognosis.
- Full text:202508111604308864成人脑脓肿临床特点及预后：单中心12年173例患者回顾性分析.pdf
