Considerations on nonclinical pharmacodynamics studies of prophylactic mpox vaccine
10.13200/j.cnki.cjb.004541
- VernacularTitle:预防用猴痘疫苗非临床药效学研究的相关考虑
- Author:
YIN Huajing
- Publication Type:Journal Article
- Keywords:
Prophylactic mpox vaccine;
Nonclinical pharmacodynamics studies;
Technical points
- From:
Chinese Journal of Biologicals
2025;38(08):1019-1024
- CountryChina
- Language:Chinese
-
Abstract:
Mpox, previously known as monkeypox, is a zoonotic disease caused by the mpox virus(MPXV), which has shown a trend of spreading globally in recent years and poses a threat to public health security. To address the potential mpox epidemic, the development of vaccine has become crucial. Nonclinical pharmacodynamics studies are an important part of vaccine development, which evaluate the immunogenicity and protective effect of vaccines in animal models, providing key evidence of efficacy to support clinical trials. This article will explore the key technical points of nonclinical pharmacodynamics studies for mpox vaccines, in combination with the nonclinical efficacy studies of similar products and the technical documents recently released, in order to provide some reference for the development of such products.
