Related factors of prognosis in patients with primary Sjogren' s syndrome complicated with renal damage
10.3969/j.issn.1006-2483.2025.04.035
- VernacularTitle:原发性干燥综合征合并肾损害患者预后的相关因素
- Author:
Fangyu LI
1
;
Yahong ZHAI
1
;
Haiyan WANG
1
;
Cuirong GAO
1
Author Information
1. Department of Rheumatology and Immunology , The First Affiliated Hospital of Xinjiang Medical University , Urumqi , Xinjiang 830054 , China
- Publication Type:Journal Article
- Keywords:
Primary Sjogren's syndrome;
Renal damage;
Prognosis
- From:
Journal of Public Health and Preventive Medicine
2025;36(4):153-156
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the related factors of prognosis in patients with primary Sjogren’s syndrome (SS) complicated with renal damage, and to provide reference for clinical development of personalized prevention and treatment measures. Methods A total of 508 patients with primary SS complicated with renal damage in the First Affiliated Hospital of Xinjiang Medical University from February 2020 to February 2022 were enrolled as study subjects. According to the prognosis status within 3 years, the enrolled patients were divided into good prognosis group (n=426) and poor prognosis group (n=82). Univariate and logistic multivariate regression analyses were adopted to analyze the influencing factors of poor prognosis. Results There were significant differences in hypertension, anemia, renal interstitial chronicity grading, and levels of globulin (GLO), immunoglobulin G (IgG) and hemoglobin between the two groups (P<0.05). Logistic multivariate analysis showed that concurrent hypertension, anemia, increased grade of renal interstitial chronicity, and elevated GLO and IgG levels were risk factors of poor prognosis in patients with primary SS complicated with renal damage, while hemoglobin level was a protective factor (OR: 1.962, 95%CI: 1.056-3.645; OR: 2.467, 95%CI: 1.153-5.278; OR: 17.796, 95%CI: 5.157-61.419; OR: 3.655, 95%CI: 1.812-7.372; OR: 5.732, 95%CI: 2.632-12.480; OR: 0.325, 95%CI: 0.165-0.640, P<0.05). Conclusion Patients with primary SS complicated with renal damage have a higher risk of poor prognosis, which is affected by factors such as hypertension, anemia, and GLO, IgG and hemoglobin levels. Clinically, it is necessary to take active prevention and treatment measures to improve the prognosis of patients.
