Correlation study between cardiac autonomic neuropathy and bone mineral density and fracture risk in patients with T2DM
10.3969/j.issn.1006-2483.2025.04.023
- VernacularTitle:2型糖尿病患者心脏自主神经病变与骨密度骨折风险的相关性
- Author:
Yinchun PENG
1
;
Jianyu REN
1
;
Xiaoxia TONG
2
Author Information
1. Department of Internal Medicine , Nanchong Mental Health Center of Sichuan Province , Nanchong , Sichuan 637000 , China
2. Department of General Medicine , Nanchong Central Hospital , Beijing Anzhen Hospital , Nanchong , Sichuan 637000 , China
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes mellitus;
Cardiac autonomic neuropathy;
Bone mineral density;
Fracture risk
- From:
Journal of Public Health and Preventive Medicine
2025;36(4):102-105
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the relationship between cardiac autonomic neuropathy (CAN) and bone mineral density (BMD) reduction and fracture risk in patients with type 2 diabetes mellitus (T2DM). Methods A total of 396 patients with T2DM admitted to Nanchong Mental Health Center of Sichuan Province were selected, and all of them underwent detection of BMD of hip, lumbar vertebra and femoral neck. Fracture risk was evaluated using the probability of major osteoporotic fracture (PMOF) and ten-year probability of hip fracture (PHF). According to the degree of fracture risk, the patients were divided into low-risk group and high-risk group. Clinical data and CAN condition of the two groups were compared. Factors influencing fracture risk in patients with T2DM were analyzed. According to CAN condition, the patients were divided into early group, diagnosed group, and severe group. The correlation between CAN score and BMD was analyzed. Results The proportion of CAN in the high-risk group was significantly higher than that in the low-risk group (P<0.05). The BMD of hip, lumbar vertebra and femoral neck was significantly lower than that in the low-risk group (P<0.05). Logistic regression analysis showed that BMD of hip (OR=0.143, 95%CI: 0.102-0.201), BMD of lumbar vertebra (OR=0.047, 95%CI: 0.022-0.100), BMD of femoral neck (OR=0.208, 95%CI: 0.168-0.257), and CAN (OR=39.409, 95%CI: 14.704-105.623) were risk factors for fracture (P<0.05). The BMD of hip, BMD of lumbar vertebra and BMD of femoral neck in the severe group, the diagnosed group, and the early group increased in order (P<0.05). CAN score was negatively correlated with the BMD of hip, BMD of lumbar vertebra and BMD of femoral neck in patients with T2DM (P<0.05). Conclusion The condition of CAN in patients with T2DM is closely related to BMD reduction, and CAN is a risk factor for fracture.
