A new perspective on tumor immunotherapy:metabolic regulation of T cells
10.3872/j.issn.1007-385x.2025.07.001
- VernacularTitle:肿瘤免疫治疗的新视角:T细胞代谢调控
- Author:
Huayu LI
1
;
Chunyang LI
1
;
Chunhong MA
1
Author Information
1. 山东大学基础医学院 实验畸形学教育部重点实验室,山东 济南 250012
- Publication Type:Journal Article
- Keywords:
CD8+T cell;
metabolic reprogramming;
tumor microenvironment(TME);
chimeric antigen receptor gene-modified T lymphocyte(CAR-T cell)
- From:
Chinese Journal of Cancer Biotherapy
2025;32(7):673-680
- CountryChina
- Language:Chinese
-
Abstract:
Despite the remarkable clinical efficacy achieved by immune checkpoint blockade(ICB)and adoptive T cell therapy,the majority of patients with solid tumors still fail to achieve long-term responses to immunotherapy.One important reason is the complex metabolic patterns and inhibitory signals within the tumor microenvironment(TME),which induce metabolic reprogramming in immune cells and thereby impair their anti-tumor efficacy.This review summarizes the metabolic preferences of CD8+T cells across various differentiation states,explores the metabolic changes that occur during their interaction with tumor cells and the TME,and discusses how these metabolic changes affect differentiation,function,and stemness of CD8+T cells.Additionally,strategies that target metabolic molecules or pathways are highlighted to enhance the antitumor ability of CD8+T cells,thereby improving the efficacy of chimeric antigen receptor gene-modified T lymphocyte(CAR-T cell)immunotherapy and ICB therapy.
