Research progress of the interleukin-17 family in the occurrence and development of interstitial cystitis/bladder pain syndrome
10.3969/j.issn.1009-8291.2025.06.014
- VernacularTitle:白细胞介素17家族在间质性膀胱炎/膀胱疼痛综合征发生发展中的研究进展
- Author:
Jiawen WANG
1
;
Yaoguang ZHANG
2
;
Jianye WANG
2
;
Xiaoye CHEN
3
Author Information
1. Department of Urology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou 350000; Department of Urology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China
2. Department of Urology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China
3. Department of Urology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou 350000
- Publication Type:Journal Article
- Keywords:
interstitial cystitis/bladder pain syndrome;
interleukin-17;
inflammation;
inflammatory reaction
- From:
Journal of Modern Urology
2025;30(6):533-537
- CountryChina
- Language:Chinese
-
Abstract:
Interleukin-17 (IL-17) and its receptor family members are involved in a variety of pathophysiological processes.Studies have shown that the IL-17 family may be closely related to the occurrence and development of interstitial cystitis/ bladder pain syndrome (IC/BPS).This paper explores the relationship between the IL-17 family and IC/BPS, introduces the members and structures of the IL-17 family, their value in inflammatory diseases, and discusses in depth the IL-17 pathways in IC/BPS and the latest research progress.Research has found that the IL-17 family is upregulated in IC/BPS, related to the exacerbation of pathological inflammatory reactions, and responsible for maintaining the chronic inflammatory state of IC/BPS patients.In addition, IL-17 is also associated with neuroinflammation, pain, and other biological effects in IC/BPS.This review aims to deepen the understanding of the mechanisms underlying IC/BPS and to provide references for the development of new therapeutic strategies.
