Safety outcomes after thrombolysis for acute ischemic stroke in patients with prior recent stroke: A meta-analysis of observational studies
- Author:
Yu Shen
1
;
Min Li
1
;
Lijun Xu
1
Author Information
- Publication Type:Journal Article
- Keywords: Intravenous thrombolysis; previous stroke; early recurrent stroke; meta-analysis
- From:Neurology Asia 2021;26(1):27-34
- CountryMalaysia
- Language:English
- Abstract: Objective: This investigation sought to evaluate the safety outcomes after thrombolysis for acute ischemic stroke in patients with prior recent stroke through meta-analysis. Methods: The databases were systematically searched for were observational studies of intravenous thrombolysis for stroke in patients with prior stroke in the past 3 months, the risk of intracranial hemorrhage and mortality. Data from eligible studies were analyzed using RevMan5.3. Results: A total of 7 studies were included in the analysis. The adjusted OR of the analysis indicated that prior stroke within 3 months of receiving intravenous thrombolysis for acute ischemic stroke would not increase the risk of intracranial hemorrhage (6 studies, the treatment group contains 1,037 and the control group 51,788) and mortality at three months (4 studies, the treatment group contains 977 and the control group 51,361 subjects). Based on the number of events, we could conclude that thrombolysis does not increase the risk of intracranial hemorrhage (3 studies, the treatment group contains 834 and the control group 48,452 subjects) and mortality at three months (3 studies, the treatment group contains 834 and the control group 48,452 subjects). Conclusion: A review of the current published literature indicates that prior stroke within 3 months of receiving intravenous thrombolysis for acute ischemic stroke does not increase the risk of intracranial hemorrhage and the 3-month mortality of patients.
- Full text:20250724111020578267.2020my0098.pdf
