Clinical characteristics of cerebrovascular disease with COVID-19: A single-center study in Manila, Philippines
- Author:
Paul Kristian Manog Jaca
1
;
Christine Anne Carandang Chacon
1
;
Raquel Mallari Alvarez
1
Author Information
- Publication Type:Journal Article
- Keywords: COVID-19; cerebrovascular disease; stroke
- From:Neurology Asia 2021;26(1):15-25
- CountryMalaysia
- Language:English
- Abstract: Background: Among the morbid neurological complications, stroke has been frequently observed in COVID-19 but there are limited reports, especially in the Philippines. This study aims to determine the clinical characteristics of COVID-19 patients with cerebrovascular disease (CVD). Methods: We performed a single-center retrospective analysis of stroke patients with COVID-19 from March to August 2020. Results: Of the 584 COVID-19 cases, 27 patients have cerebrovascular disease, with rate of COVID-19 related CVD at 4.62%. COVID-19 with CVD were younger than those without COVID-19 (58.23 vs 61.53 years). The median admitting NIHSS was mild for both groups (4 vs 5) and the vascular risk factors of these groups were similar. The median time of onset of CVD at 7 days from onset of COVID-19. Deranged levels of procalcitonin, D-dimer, ferritin, CRP, and LDH were elevated and greater in the large artery atherothrombosis. Anti-platelet therapy was given in 4 (20%) while 16 (80%) received anticoagulation. For intracranial hemorrhage, 6 out of 7 (86 %) were admitted without prior COVID-19 symptom; hence, a causal relationship is difficult to establish. Conclusion: Less than 5 % of the COVID-19 patients present with CVD. They are younger but share similar vascular risk factors with COVID-19 negative stroke patients. There is a possible association between COVID-19 and acute ischemic stroke. Large artery atherothrombosis are more common in patients with COVID-19 this type showed more deranged laboratory investigation. A causal relationship between intracranial hemorrhage and COVID-19 is difficult to establish; thus, further study regarding this is merited.
- Full text:20250724110421295797.2020my0097.pdf
