Cervical spinal ependymoma in a child with Down syndrome: A case report and review of the literature
- Author:
Thitiporn Fangsaad
1
Author Information
- Publication Type:Journal Article
- Keywords: Spinal ependymoma; Down syndrome; oncogene
- From:Neurology Asia 2020;25(4):619-621
- CountryMalaysia
- Language:English
- Abstract: Down syndrome is one of the most common chromosomal abnormalities. They have an increased risk of leukemia and other hematologic malignancies due to 3 oncogenes on chromosome 21. However, solid tumors seem to be underrepresented in Down syndrome. Central nervous system (CNS) tumors are even less common, although, there is no antioncogene for glial tumors on chromosome 21. Down syndrome with ependymoma is a rare association. We report a case of Down syndrome with cervical spinal ependymoma who presented with torticollis and left arm weakness. MRI was compatible with ependymoma and pathology confirmed ependymoma grade II. The patient underwent tumor removal surgery and local radiation therapy. Follow-up MRIs in one year showed resolution of the enhancing lesion, with remarkable improvement of motor power.
- Full text:20250724101120013997.2020my0090.pdf
