Clinical features of anti-leucine rich glioma inactivated 1 antibody autoimmune encephalitis
10.19845/j.cnki.zfysjjbzz.2025.0097
- VernacularTitle:抗LGI1抗体自身免疫性脑炎的临床分析
- Author:
Yongfang LI
1
;
Yi TANG
2
;
Qi QIN
2
Author Information
1. 首都医科大学宣武医院神经内科，神经疾病高创中心，北京100053;郑州市第一人民医院神经内科，河南 郑州 450000
2. 首都医科大学宣武医院神经内科，神经疾病高创中心，北京100053
- Publication Type:Journal Article
- Keywords:
Autoimmune encephalitis;
Leucine rich glioma inactivated 1 antibody;
Epilepsy;
Cognitive impairment;
Mental and behavioral disorders
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(6):512-516
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical manifestations and prognosis of patients with anti-leucine rich glioma inactivated 1（LGI1）antibody encephalitis. Methods A retrospective analysis was performed for the data of patients with anti-LGI1 antibody encephalitis who were hospitalized in Department of Neurology，Xuanwu Hospital，Capital Medical University，from September 2019 to December 2023，including clinical features，treatment，and prognosis. Results A total of 80 patients were enrolled，including 48 male patients and 32 female patients. Of all 80 patients，51（63.8%）had the initial symptom of epilepsy，13（16.3%）had the initial symptom of faciobrachial dystonic seizures，26（32.5%）had the initial symptom of cognitive impairment，and 12（15%）had the initial symptom of mental and behavioral disorders. As for comorbidities，there were 28 patients（35%）with hyponatremia，22（27.5%）with Hashimoto's thyroiditis，and 5（6.25%）with tumor. All 80 patients tested positive for serum LGI1 antibody，and 69（86.3%）tested positive for LGI1 antibody in cerebrospinal fluid. Among the 80 patients，37（46.25%）had abnormalities on magnetic resonance imaging，and 30 had abnormalities on 18F-FDG PET/CT. There were 50 patients with abnormalities on video electroencephalography. A total of 77 patients received first-line immunotherapy，and after follow-up for 1 year，19.4% of the patients had the sequela of seizure，59.7% of the patients had deterioration of the memory，and 48.6% of the patients had mental and behavioral disorders. Conclusion Epilepsy，cognitive impairment，and mental and behavior disorders are the most common manifestations of anti-LGI1 antibody encephalitis. There is generally a good prognosis after immunotherapy，with the sequelae of cognitive impairment and mental and behavioral disorders.
- Full text:2025071710573437878抗LGI1抗体自身免疫性脑炎的临床分析.pdf
