Frontier research and future prospects： The application of vaccines，gene editing，and big data in autoimmune encephalitis
10.19845/j.cnki.zfysjjbzz.2025.0094
- VernacularTitle:前沿研究与未来展望：疫苗、基因编辑和大数据在自身免疫性脑炎中的应用
- Author:
Yan JIA
1
;
Jun GUO
1
Author Information
1. Department of Neurology，The Second Affiliated Hospital of Air Force Medical University，Xi’an 710038，China
- Publication Type:Journal Article
- Keywords:
Autoimmune encephalitis;
Vaccine;
Gene editing;
Big data
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(6):498-500
- CountryChina
- Language:Chinese
-
Abstract:
Autoimmune encephalitis（AE）refers broadly to a group of encephalitic disorders mediated by autoimmune mechanisms. AE is characterized by complex pathogeneses and diverse clinical manifestations，and there are still numerous challenges in the diagnosis and treatment of AE. With the development of frontier technologies such as vaccines，gene editing，and big data，new opportunities have emerged for transforming the diagnosis and treatment strategies for AE. Vaccines play a dual role in AE： on the one hand，they can prevent infections； on the other hand，they may trigger autoimmune responses through molecular mimicry. Emerging nanovaccine technologies are expected to achieve safer and more effective immunomodulation. Gene editing techniques，especially the CRISPR-Cas9 system，have shown potential in targeted regulation of the function of immune cells and repair of nervous tissue，which provides new pathways for precise intervention in the treatment of AE. The application of big data technologies，including artificial intelligence，natural language processing，and deep learning，has promoted the early diagnosis of AE and the development of individualized treatment regimens. This article reviews the research advances and clinical prospects of these cutting-edge technologies in AE，in order to provide insights and references for the development of precision medicine，interdisciplinary collaboration，and future treatment strategies for AE.
- Full text:2025071710242225444前沿研究与未来展望：疫苗、基因编辑和大数据在自身免疫性脑炎中的应用.pdf
