Research advances in fibrinogen β-148C/T gene polymorphisms and patent foramen ovale comorbid with ischemic stroke
10.19845/j.cnki.zfysjjbzz.2025.0090
- VernacularTitle:纤维蛋白原β-148C/T基因多态性与PFO合并缺血性卒中的研究进展
- Author:
Fei YI
1
;
Xiujuan SONG
1
Author Information
1. Department of Neurology， The Second Hospital of Hebei Medical University， Key Laboratory of Clinical Neurology，Ministry of Education，Key Laboratory of Neurology of Hebei Province，Shijiazhuang 050000， China
- Publication Type:Journal Article
- Keywords:
Fibrinogen β-148C/T;
Patent foramen ovale;
Ischemic stroke;
Genetic polymorphism
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(5):477-480
- CountryChina
- Language:Chinese
-
Abstract:
Between PFO and ischemic stroke has been confirmed， and the concept of PFO-AS was officially established in 2020. Contradictory embolism is considered the main pathogenesis of PFO-AS. Fibrinogen， a coagulation factor mainly synthesized by the liver， is closely related to thrombosis and is also an important risk factor for occurrence and recurrence of ischemic stroke， Its level is closely related to polymorphism of fibrinogen promoter. Currently analyzed fibrinogen β（FGβ） there more than 10，which HindⅢ（β-148C/T） gene polymorphism in the FGβ gene promoter region is closely related to plasma fibrinogen level and ischemic stroke. Therefore， a better understanding of genetic variation and susceptibility gene may be one of the best methods to help us prevent，diagnose，treat and improve the prognosis of stroke in the early stages.
- Full text:2025071709391331271纤维蛋白原β-148C_T基因多态性与PFO合并缺血性卒中的研究进展.pdf
