Syndrome evolution of acute-on-chronic liver failure and ideas for diagnosis and treatment
- VernacularTitle:慢加急性肝衰竭的证候演变及证治思路
- Author:
Qianqian ZHANG
1
;
Yu HUANG
1
;
Kewei SUN
1
Author Information
- Publication Type:Journal Article
- Keywords: Acute-On-Chronic Liver Failure; Symptom Complex; Dampness Heat; Stagnant Heat; Spleen Deficiency
- From: Journal of Clinical Hepatology 2025;41(6):1008-1015
- CountryChina
- Language:Chinese
- Abstract: Acute-on-chronic liver failure （ACLF） is an acute and critical illness with a high short-term mortality rate， and current therapies mainly focus on elimination of causes， organ support， and prevention of complications. Although liver transplantation is the most effective treatment modality， its clinical application is limited， and traditional Chinese medicine has shown significant advantages and characteristics in the treatment of ACLF. In traditional Chinese medicine， ACLF is classified into the same category as diseases such as “jaundice”， and unlike traditional jaundice which is mostly characterized by excess and heat syndromes， the syndrome of ACLF has gradually transformed from Yang jaundice to Yin jaundice due to the changing disease spectrum of ACLF. With reference to the pathogenesis of ACLF in Western medicine and traditional Chinese medicine theories， this article discusses the essential pathogenesis of ACLF in traditional Chinese medicine， explores the evolution of ACLF syndromes， and reviews the research advances in the clinical efficacy and mechanisms of traditional Chinese medicine based on the three-factor differentiation-based treatment of damp-heat， blood stasis-heat， and spleen deficiency， as well as the safety of spleen-strengthening and Yang-warming drugs in the clinical treatment of ACLF， in order to provide ideas， methods， and evidence for the application of traditional Chinese medicine in ACLF.
