Advances in the treatment of mitochondrial diseases
10.19845/j.cnki.zfysjjbzz.2025.0081
- VernacularTitle:线粒体病的治疗进展
- Author:
Jiayin WANG
1
;
Chuanzhu YAN
1
Author Information
1. 山东大学齐鲁医院（青岛）神经内科，山东 青岛 266035;山东省罕见病线粒体医学重点实验室，山东 济南 250012
- Publication Type:Journal Article
- Keywords:
Mitochondrial diseases;
Treatment;
Clinical manifestations;
Diagnosis
- MeSH:
Diagnosis
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(5):427-433
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondrial diseases are a group of hereditary disorders characterized by impaired oxidative phosphorylation in the mitochondrial respiratory chain caused by defects in either mitochondrial DNA or nuclear DNA， and such diseases have complex and diverse clinical manifestations and often involve multiple organs and systems， with the main manifestation of lesions in the nervous system and muscles due to their high energy demands. At present， there is still a lack of effective therapies for most mitochondrial diseases， and therefore， multidisciplinary management is essential in clinical practice， integrating various therapeutic approaches to provide personalized treatment regimens for patients with mitochondrial diseases. The primary treatment principle involves the timely correction of pathological and physiological abnormalities through pharmacological interventions， dietary modifications， and exercise management， along with the prompt treatment of system-specific impairments and the prevention of potential complications.
- Full text:2025071616122171652线粒体病的治疗进展.pdf
