A network analysis of depression and autonomic symptoms in Parkinson disease
10.19845/j.cnki.zfysjjbzz.2025.0023
- VernacularTitle:帕金森病抑郁与自主神经症状网络分析
- Author:
Tong LIU
1
;
Yong YOU
1
Author Information
1. Department of Neurology， The Second Affiliated Hospital of Hainan Medical University， Haikou 570100， China
- Publication Type:Journal Article
- Keywords:
Parkinson’ disease;
Depression;
Autonomic nervous function;
Network analysis
- MeSH:
Parkinson Disease;
Depression
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(2):115-120
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between depression and autonomic nervous function in Parkinson disease （PD）， and to provide a basis for clinical treatment. Methods Clinical and neurocirculation data were collected from 168 PD patients who attended Department of Neurology， The Second Affiliated Hospital of Hainan Medical College， from July 2022 to July 2023， and according to the score of Beck Depression Inventory， the patients were divided into depression in PD （dPD） group with 57 patients and non-dPD （nPD） group with 111 patients. General clinical data were collected from all patients. The supine-to-standing TCD test was performed for all patients to record systolic blood pressure （SBP）， diastolic blood pressure （DBP）， heart rate （HR）， and the mean velocity （Vm）， pulsatility index （PI）， and resistance index （RI） of the middle cerebral artery （MCA） at 1， 3， and 5 minutes in both the supine and standing positions. A network was constructed for depression symptoms in PD. Results In the network of non-motor symptoms in PD， depression showed the highest centrality and the strongest predictability and was strongly correlated with sleep/fatigue and mood/cognition， with a strength centrality stability coefficient （CS strength） of 0.440. Compared with the nPD group， the dPD group had significantly lower supine HR， ∆HR， Vm in the standing position， and ∆Vm%， a significantly greater ∆DBP， and a significantly higher proportion of patients with dizziness with orthostatic hypotension or orthostatic cerebral hypoperfusion （P<0.05）. Depression was positively correlated with ∆SBP， ∆DBP， Vm in the supine position， and RI in the standing position， and it was negatively correlated with ∆HR， DBP in the supine position， HR in the supine position， and ∆PI （CS strength=0.375 and 0.222）. Conclusion Impairment of cardiovascular and cerebral autonomic nervous function might be involved in the pathogenesis of depression in PD， and intervention of depression can help improve the overall non-motor symptoms of PD， with sleep， fatigue， and cognition as the effective targets for improving depression in PD.
- Full text:2025071514070052362帕金森病抑郁与自主神经症状网络分析.pdf
