Research advances in microglial glucose metabolic reprogramming in central nervous system diseases
10.19845/j.cnki.zfysjjbzz.2025.0014
- VernacularTitle:小胶质细胞糖代谢重编程在中枢神经系统疾病中的研究进展
- Author:
Lingyun BAI
1
;
Jingjing KANG
2
;
Xiang CAO
3
Author Information
1. 南京师范大学鼓楼医院生命健康研究院，江苏 南京 210008
2. 黄河科技学院医学院生化教研室，河南 郑州 450063
3. 南京师范大学鼓楼医院生命健康研究院，江苏 南京 210008;黄河科技学院医学院生化教研室，河南 郑州 450063
- Publication Type:Journal Article
- Keywords:
Microglial cells;
Glucose metabolism;
Glucose metabolic reprogramming;
Central nervous system diseases
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(1):65-69
- CountryChina
- Language:Chinese
-
Abstract:
Serving as cerebral macrophages， microglial cells are meticulously regulated by the microenvironment of the central nervous system.In response to various environmental and cellular stresses， microglial cells are rapidly activated and exhibit either pro-inflammatory or anti-inflammatory phenotypes to maintain brain tissue homeostasis， and during this process， significant changes are observed in glucose metabolism of microglial cells. Aerobic glycolysis is the primary energy source for pro-inflammatory microglial cells， while oxidative phosphorylation is the energy source for anti-inflammatory microglial cells.This article systematically elaborates on glucose metabolism and glucose metabolic reprogramming pathways in microglial cells， as well as their role in central nervous system diseases. In addition， this article also discusses the potential of targeting glucose metabolic reprogramming in microglial cells for the treatment of related diseases.
- Full text:2025071512512145586小胶质细胞糖代谢重编程在中枢神经系统疾病中的研究进展.pdf
