Regulation of Renal Interstitial Fibrosis-related Pathways by Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20250421
- VernacularTitle:中医药调控肾间质纤维化相关通路研究进展
- Author:
Dandan WEI
1
;
Shanshan LI
2
;
Yongjie WANG
3
;
Hongling WANG
4
;
Zongyao WU
5
;
Qingbo WANG
1
Author Information
1. The First Affiliated Hospital of Henan University of Chinese Medicine， Zhengzhou 450000， China
2. The First Clinical Medical College of Henan University of Chinese Medicine， Zhengzhou 450000， China
3. The Third People's Hospital of Henan Province， Zhengzhou 450000， China
4. Henan Province Staff Hospital， Zhengzhou 450000， China
5. Xizang University Tibetan Medicine， Lhasa 850000， China
- Publication Type:Review
- Keywords:
renal interstitial fibrosis;
traditional Chinese medicine;
signaling pathway;
mechanism of action;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(16):254-265
- CountryChina
- Language:Chinese
-
Abstract:
Renal interstitial fibrosis （RIF） is a common pathological change process from the development of various chronic nephropathies to the end stage， and it is an important histological manifestation of renal function decline. At present， no effective anti-fibrosis drugs have been found in clinical practice. In recent years， with the continuous development of traditional Chinese medicine （TCM） pharmacology， molecular biology， system biology， and network pharmacology， the research on regulating RIF with TCM monomer， single TCM， TCM compound， Chinese patent medicine， and TCM injection is deepening. Among them， Jianpi Yishen recipe， Shendi Bushen capsules， Jianzhong Bushen Xiaozheng decoction， Liuwei Dihuangtang， and Lycium barbarum polysaccharides can regulate transforming growth factor-β/small mother against decapentaplegic （TGF-β1/Smads）， Wnt/β-catenin， and neurogenic locus notch homolog protein （Notch） signaling pathways. Wulingsan， Zhenwutang， pachymic acid ZA， pachymic acid ZC， and pachymic acid ZD， which mainly induce diuresis， can regulate the Wnt/β-catenin signaling pathway. Hirudin， curcumin， and Fuzheng Huayu recipe， which mainly promote blood circulation， can inhibit inflammation-related pathways such as p-nuclear transcription factor-κB （NF-κB）， Toll-like receptor 4/p-nuclear transcription factor-κB （TLR4/NF-κB）， and Janus kinase 2/signal transducer and activator of transcription 3 （JAK/STAT）， so as to achieve anti-inflammatory and anti-oxidation effects and alleviate the progression of RIF. Shenshuai Xiezhuo decoction， Shenkang injection， and Shenshuai recipe， which are mainly used for invigorating Qi， removing blood stasis， and removing turbidity， can inhibit transdifferentiation of pericytes-myofibroblasts through vascular endothelial growth factor receptor （VEGFR） signaling pathway. At present， there are many studies on the regulation of the RIF signaling pathway by TCM， but there is a lack of a systematic summary. In this study， by combing the signaling pathway of TCM in the treatment of RIF， the effective target of TCM treatment is screened， and its possible mechanism is found， which provides new ideas for clinical treatment and new drug research and development.
