Therapeutic effect of Shenqi Yizhi Granules on prodromal Alzheimer disease in plateau areas： A study based on multimodal magnetic resonance imaging
10.19845/j.cnki.zfysjjbzz.2024.0207
- VernacularTitle:基于多模态MRI探讨参芪益智颗粒对高原地区前驱期阿尔茨海默病患者的疗效观测
- Author:
Baogen RU
1
;
Yonghai ZHANG
2
;
Aiqin ZHU
3
Author Information
1. 青海省人民医院老年医学科，青海 西宁 810000;青海大学研究生院，青海 西宁 810000;青海省老年疾病临床研究中心，青海 西宁 810000
2. 青海省人民医院影像中心，青海 西宁 810000
3. 青海省人民医院老年医学科，青海 西宁 810000;青海省老年疾病临床研究中心，青海 西宁 810000
- Publication Type:Journal Article
- Keywords:
Multimodal magnetic resonance imaging;
Shenqi Yizhi Granules;
Prodromal Alzheimer disease;
Plateau area;
Multidimensional cognition
- From:
Journal of Apoplexy and Nervous Diseases
2024;41(12):1085-1091
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Shenqi Yizhi Granules on brain structure and function in prodromal Alzheimer disease（pAD） under hypoxic conditions based on MRI. Methods A total of 77 female Han Chinese patients， aged 50‒85 years， who had at least 6 years of education and long-term residence in Qinghai region and met the inclusion criteria for pAD were enrolled as subjects. They were randomly divided into drug group （39 patients receiving Shenqi Yizhi Granules） and control group （38 patients receiving placebo） for 24 weeks of clinical observation. Related data were collected from all subjects， including clinical information， cognitive and neuropsychological assessments， diffusion tensor imaging （DTI） data， and rs-fMRI data. Results Cognitive and neuropsychological assessments showed that after treatment， the drug group had significant increases in MoCA， AVTL， SDMT， and CFT-copy scores and significant reductions in ADAS-cog and GDS scores（P<0.05）， while the control group had a significantly increase in ADAS-cog score （P<0.001）； compared with the control group after treatment， the drug group had significantly higher MoCA and AVTL scores （P<0.05） and a significantly lower ADAS-cog score （P<0.01）. DTI results showed that the drug group had significant increases in axial diffusivity （AD） values of multiple brain regions after treatment （P<0.05）. The results of rs-fMRI showed that after treatment， the drug group had significant increases in the amplitude of low-frequency fluctuation （ALFF） in the right temporal middle gyrus， the triangular part of the inferior frontal gyrus， and the medial cingulate gyrus and paracingulate gyrus and significant reductions in ALFF in the left cerebellar hemisphere Crus1 lobule， superior occipital gyrus， and supramarginal gyrus， and compared with the control group， the drug group had a significant increase in ALFF in the right dorsolateral superior frontal gyrus （P<0.05）. After treatment， the drug group had significant increases in the regional homogeneity （ReHo） values of the left triangular part of the inferior frontal gyrus and the inferior occipital gyrus and a significant reduction in the ReHo value of the left cerebellar hemisphere Crus1 lobule （P<0.05）， and compared with the control group， the drug group had a significant increase in the ReHo value of the left inferior parietal gyrus（P<0.05）. Conclusion Shenqi Yizhi Granules can effectively improve overall cognition and the function of multiple cognitive domains in pAD patients living in plateau regions by modulating the microstructure of white matter and spontaneous neuronal activity in cognitive-related brain regions.
- Full text:2025071010372646016基于多模态MRI探讨参芪益智颗粒对高原地区前驱期阿尔茨海默病患者的疗效观测.pdf
