Research advances in the mechanism of ferroptosis， its role in intracerebral hemorrhage， and related drug therapies
10.19845/j.cnki.zfysjjbzz.2024.0073
- VernacularTitle:铁死亡的发生机制及其在脑出血中的作用与相关药物治疗研究进展
- Author:
Yangyang WEI
1
;
Cheng LIANG
1
Author Information
1. 兰州大学第二临床医学院，甘肃 兰州 730000;兰州大学第二医院，甘肃 兰州 730030
- Publication Type:Journal Article
- Keywords:
Ferroptosis;
Intracerebral hemorrhage;
Secondary brain injury
- From:
Journal of Apoplexy and Nervous Diseases
2024;41(4):372-376
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a newly discovered iron-dependent form of non-apoptotic cell death and is involved in the pathological process of many diseases. Intracerebral hemorrhage is a disease with high morbidity， mortality， and disability rates and is a common acute and critical illness in the department of neurology， and it often has a poor prognosis and greatly threatens human health. Primary brain tissue injury caused by intracerebral hemorrhage and secondary injury associated with cytotoxicity， neuroinflammation， and oxidative stress are the main reasons leading to poor prognosis， among which secondary brain injury after intracerebral hemorrhage is a difficulty in clinical treatment at present. Studies have shown that ferroptosis is closely associated with the course of secondary brain injury after intracerebral hemorrhage. In-depth research on the mechanism of ferroptosis after intracerebral hemorrhage and the prospect of drug therapies will provide new ideas and new targets for the diagnosis and treatment of secondary brain injury after intracerebral hemorrhage.
- Full text:2025071009164052765铁死亡的发生机制及其在脑出血中的作用与相关药物治疗研究进展.pdf
