Exhaled Volatile Organic Compounds Analysis in Patients with Pulmonary Complications after Abdominal Surgery
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2025.0318
- VernacularTitle:腹部术后肺部并发症患者呼出气挥发性有机化合物分析
- Author:
Bin WANG
1
;
Xiaoli ZHANG
2
;
Xiaochun YANG
2
;
Jingyu WANG
3
;
Youzhong AN
4
;
Yi FENG
5
Author Information
1. Department of Anesthesiology， Peking University People’s Hospital， Beijing 100044， China//Department of Critical Care Medicine， Peking University People’s Hospital， Beijing 100044， China
2. Shimadzu CO.， LTD. China Innovation Center， Beijing 100020， China
3. Department of Experimental Science and Technology， School of Public Health， Peking University， Beijing 100083， China//Center for Vaccine Research， School of Public Health， Peking University， Beijing 100083， China//Peking University Medical and Health Analysis Center， Beijing 100083， China
4. Department of Critical Care Medicine， Peking University People’s Hospital， Beijing 100044， China
5. Department of Anesthesiology， Peking University People’s Hospital， Beijing 100044， China
- Publication Type:Journal Article
- Keywords:
intensive care unit;
tracheal intubation;
pulmonary complications;
exhaled breath analysis;
volatile organic compounds
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2025;46(3):528-534
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo identify the characteristic exhaled volatile organic compounds （VOCs） associated with postoperative pulmonary complications （PPCs） in patients after abdominal surgery. MethodsThis study prospectively enrolled 76 patients with tracheal intubation who were transferred to intensive care unit （ICU） after abdominal surgery at Peking University People's Hospital between December 10， 2022 and June 30， 2023. The patients' basic information was collected during their perioperative period， and their exhaled VOCs were collected within 24 hours after their admission to the ICU， and then analyzed by gas chromatography and mass spectrometry （GC-MS）. According to whether PPCs occurred 24 hours after surgery， the patients were divided into PPCs group （n=44） and non-PPCs group （n=32）， and the differences of VOCs were compared between the two groups. Lasso regression analysis was used to screen the valuable variables of VOCs， and Logistics regression analysis to determine the characteristic VOCs associated with the occurrence of PPCs. ResultsAmong the 76 patients， 44 had PPCs and 32 had no PPCs. Lasso regression analysis screened 4 PPCs-related compounds from exhaled VOCs of two groups for further analysis and Logistics regression analysis showed that the increase of 1-Hexadecanol content in exhaled breath was significantly correlated with the occurrence of PPCs （OR： 1.000， P=0.002）. ConclusionThis study indicated that the increased content of 1-Hexadecanol in patients' exhaled breath after abdominal surgery may be associated with the occurrence of PPCs.
