Expression levels of serum secreted frizzled-related protein 5, heat shock protein 60 and solute carrier family 16 member 11 in patients with gestational diabetes mellitus and their relationships with insulin resistance
- VernacularTitle:妊娠期糖尿病患者血清分泌性卷曲相关蛋白-5、热休克蛋白60、溶质载体家族16成员11的表达及其与胰岛素抵抗的关系
- Author:
Man WEI
1
;
Wenhe YUAN
;
Hongyun LIU
;
Dimeng MA
;
Kanglu YAN
;
Ning HAN
Author Information
- Publication Type:Research Article
- Keywords: secreted frizzled-related protein 5; heat shock protein 60; solute carrier family 16 member 11; gestational diabetes mellitus; insulin resistance
- From: Journal of Clinical Medicine in Practice 2024;28(20):60-65
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression levels of secreted frizzled-related protein 5 (sFRP5), heat shock protein 60 (HSP60) and solute carrier family 16 member 11 (
SLC16A11 ) in serum of patients with gestational diabetes mellitus (GDM) and their relationships with insulin resistance. Methods A total of 120 GDM patients in the hospital from January 2022 to December 2023 were selected as study group, and another 120 healthy pregnant women in the same period were selected as control group. The expression levels of serum sFRP5, HSP60 andSLC16A11 were detected; the levels of insulin resistance-related indicators[fasting blood glucose (FBG), fasting insulin (FINS), and homeostasis model assessment of insulin resistance (HOMA-IR)]were measured and calculated; the Pearson's correlation method was used to analyze the correlations of serum sFRP5, HSP60 andSLC16A11 with insulin resistance; the Logistic regression andysis and receiver operating characteristic (ROC) curve analysis were used to assess the relationships of serum sFRP5, HSP60 andSLC16A11 with GDM. Results The serum sFRP5 expression in the study group was significantly lower than that in the control group, while the serum HSP60,SLC16A11 , FBG, FINS and HOMA-IR levels were significantly higher than those in the control group (P < 0.05). Pearson's correlation analysis showed that serum sFRP5 was negatively correlated with HSP60,SLC16A11 , FBG, FINS and HOMA-IR (P < 0.05); serum HSP60 was positively correlated withSLC16A11 , FBG, FINS and HOMA-IR (P < 0.05); serumSLC16A11 was positively correlated with FBG, FINS and HOMA-IR (P < 0.05). Multivariate Logistic regression analysis revealed that HSP60,SLC16A11 , FBG, FINS and HOMA-IR were risk factors for GDM in pregnant patients, while sFRP5 was a protective factor (P < 0.05). The area under the curve (AUC) for the combined diagnosis of GDM in pregnant patients by serum sFRP5, HSP60 andSLC16A11 was 0.924, indicating that the combined diagnostic value of three indicators was superior to that of each individual indicator (allP < 0.05). Conclusion GDM patients exhibit decreased serum sFRP5 level and increased HSP60 andSLC16A11 levels; three indicators are factors influencing the occurrence of GDM in pregnant patients, and are associated with insulin resistance; the combination of three indicators exhibits high diagnostic efficacy for GDM.
