Assessment of the Viable Fraction of Hepatocytes by Mangafodipir Trisodium Enhanced Functional MR Imaging: Preliminary Report in Animal Models.
10.3348/jkrs.2007.56.2.161
- Author:
Soon Gu CHO
1
;
Yong Sun JEON
;
Kyung Hee LEE
;
Jang Ho SONG
;
In Suh PARK
;
Seung Baik HAN
;
Chang Hae SUH
Author Information
1. Department of Radiology, Inha University College of Medicine, Incheon, Korea. soongucho@hanmail.net
- Publication Type:Original Article
- Keywords:
Liver;
Liver, function;
Magnatic resonance (MR), volume measurement;
Animals
- MeSH:
Animals*;
Bilirubin;
Dogs;
Hepatocytes*;
Liver;
Magnetic Resonance Imaging*;
Models, Animal*;
Necrosis
- From:Journal of the Korean Radiological Society
2007;56(2):161-170
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: We designed this study to evaluate the feasibility of using mangafodipir trisodium enhanced functional liver imaging (MT-FLI) for assessing the viable fraction of hepatocytes (VFH) in the liver. MATERIALS AND METHODS: We evaluated the change of VFH with using MT-FLI before and after inducing acute hepatic necrosis (AHN) with CCl4 in the liver of 15 beagle dogs. The MR imaging was performed on a 1.5T MRI unit with using the EFGRE-3D sequence (TR/TE=4.7/1.1 msec; flip angle: 20.0degree). We evaluated the linear dependence of the density of viable hepatocytes in AHN on the MR images as compared to that in the corresponding normal livers (DAHN/DN) on the VFH in their pathologic specimens, and the change of the VFH from the MT-FLI on that of the laboratory findings (AST, ALT, albumin, bilirubin, PT, ICG-R15) before and after AHN induction. RESULTS: The mean+/-SD of the VFH from the MT-FLI in AHN was 61.2+/-10.7% of that of the normal ones. The DAHN/DN showed strong positive linear dependence on the VFH in their pathologic specimens (β=.769, p<.05). The change of the VFH from MT-FLI showed high linear dependence on that of all the above-mentioned laboratory findings (β<-.933 or >.938, p<.05). CONCLUSION: The MT-FLI seems to be a feasible method for measuring VFH in the liver.
