The regulatory role of tissue-resident memory T cells in chronic liver diseases and associated therapeutic targets
- VernacularTitle:组织驻留记忆T细胞在慢性肝病中的调控机制与治疗靶点
- Author:
Jin LIN
1
;
Yu ZENG
1
;
Zhanfei TIAN
1
;
Xiaoli FAN
1
Author Information
- Publication Type:Review
- Keywords: Tissue-resident Memory T Cells; Liver Diseases; Immunotherapy
- From: Journal of Clinical Hepatology 2025;41(5):975-982
- CountryChina
- Language:Chinese
- Abstract: Tissue-resident memory T cells （TRM cells） are a subset of memory T cells that reside in tissues， exhibit tissue specificity， and do not recirculate. When potential hazards threaten the liver， such as pathogen invasion （bacteria， viruses， etc.） and excessive autoimmune responses， TRM cells are essential as the first line of immune defense， playing an important role in viral hepatitis， autoimmune liver disease， metabolic dysfunction-associated fatty liver disease， liver cirrhosis， and liver transplantation. Here， we present the immunophenotypes of TRM cells in the liver and their surface markers and transcriptional profiles， aiming to clarify the role of TRM cells in chronic liver diseases and explore their potential function as therapeutic targets in immunotherapy.
