Molecular mechanisms and clinical applications of tumor budding in hepatocellular carcinoma
- VernacularTitle:肿瘤出芽在肝细胞癌中的分子机制及临床应用价值
- Author:
Hongbin ZHANG
1
;
Kai TAN
1
;
Zhenyu YANG
1
;
Shengxiong JIA
1
;
Xilin DU
1
Author Information
- Publication Type:Review
- Keywords: Carcinoma， Hepatocellular; Tumor Budding; Prognosis
- From: Journal of Clinical Hepatology 2025;41(5):963-967
- CountryChina
- Language:Chinese
- Abstract: Tumor budding is a distinct pathomorphological feature observed in various types of solid tumor. In recent years， tumor budding has been recognized as an important biological feature associated with tumor invasion and metastasis， and it has become a new focus in the research on tumor progression. Although studies have explored the role of tumor budding in different types of tumor， there are studies in the field of hepatocellular carcinoma （HCC）. This article systematically reviews the research advances in tumor budding in HCC， with a focus on the mechanism of tumor budding， the association between tumor budding and tumor progression， and the potential application of tumor budding in prognostic assessment， in order to provide new insights and strategies for the early diagnosis and treatment of HCC.
