Bone marrow mesenchymal stem cell exosomes suppress JAK/STAT signaling pathway in acute myeloid leukemia in vitro
10.1007/s44313-024-00051-5
- Author:
Sahar JALILIVAND
1
;
Maryam NABIGOL
;
Mehdi BAKHTIYARIDOVVOMBAYGI
;
Ahmad GHAREHBAGHIAN
Author Information
1. Department of Laboratory Hematology and Blood Bank, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
- Publication Type:RESEARCH
- From:Blood Research
2024;59():43-
- CountryRepublic of Korea
- Language:English
-
Abstract:
Results:The exosome characterization results confirmed that most isolated nanoparticles exhibited a round morphology, expressed CD9, CD63, and CD81, which are specific protein markers for exosome identification, and ranged between 80 and 100 nm in diameter. Furthermore, qRT-PCR analysis revealed a significant downregulation of JAK2, STAT3, and STAT5 in HL-60 cells treated with 100 μg/mL of BM-MSC exosomes.
Conclusion:Since JAK/STAT signaling contributes to AML survival, our findings suggest that the downregulation of JAK/STAT genes by BM-MSC exosomes in leukemic cells may aid in designing a potent therapeutic strategy for AML treatment.
