Opportunities and challenges of"remote-controlling"CAR-T cells for tumor therapy
10.3872/j.issn.1007-385x.2025.05.001
- VernacularTitle:"遥控"CAR-T细胞治疗肿瘤的机遇与挑战
- Author:
Wenhui RUAN
1
;
Rui HOU
;
Ming SHI
Author Information
1. 徐州医科大学 医学影像学院,江苏 徐州 221002
- Publication Type:Journal Article
- Keywords:
chimeric antigen receptor gene-modified T lymphocyte(CAR-T cell);
tumor immunotherapy;
in vivo behavior;
remote control
- From:
Chinese Journal of Cancer Biotherapy
2025;32(5):453-459
- CountryChina
- Language:Chinese
-
Abstract:
Chimeric antigen receptor gene-modified T lymphocytes(CAR-T cells)have made significant progress in the treatment of hematologic malignancies.However,the uncertainties and lack of controllability associated with their in vivo behavior remain major limitations to their clinical application.Uncontrolled or inappropriate activation of CAR-T cells at unintended locations can lead to reduced antitumor efficacy or unpredictable adverse reactions.Enabling CAR-T cells to exhibit predictable and controllable behavior in vivo,with activation occurring at the right location and at the appropriate intensity,holds the potential to significantly enhance their antitumor effectiveness and minimize adverse effects.This article systematically reviews recent strategies for"remotely controlling"CAR-T cell activity in vivo through innovative designs that allow precise regulation of CAR-T cell activity and behavior.Achieving safe,targeted,and efficient antitumor responses represents one of the key directions for the future development of CAR-T cell therapies.
