Research progress on techniques for detection of tick-borne encephalitis virus infections
10.16250/j.32.1915.2024191
- VernacularTitle:蜱传脑炎病毒感染检测技术研究进展
- Author:
Zhuofan LIU
1
;
Hao XIE
1
;
Xiaoliang SUN
2
;
Tao XIA
2
;
Junhui GUO
1
Author Information
1. School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, Hubei 430070, China
2. Wuhan Easy Diagnosis Biomedicine Co., Ltd, Wuhan, Hubei Province, China
- Publication Type:Journal Article
- Keywords:
Tick-borne encephalitis virus;
Tick-borne encephalitis;
Serological test;
Nucleic acid test
- From:
Chinese Journal of Schistosomiasis Control
2025;37(2):209-216
- CountryChina
- Language:Chinese
-
Abstract:
Tick-borne encephalitis is a central nervous system disease caused by infections with tick-borne pathogens, which is characterized by severe clinical symptoms, multiple sequelae, and a high fatality rate. Currently, there is no cure for tick-borne encephalitis. Tick-borne encephalitis virus (TBEV) is the most common pathogen of tick-borne encephalitis. Therefore, rapid and accurate detection of TBEV contributes to reducing the mortality of tick-borne encephalitis, improving patients' prognosis, and reducing the risk of TBEV transmission. The currently available serological tests for detection of TBEV infections mainly include neutralization test, enzyme-linked immunosorbent assay (ELISA), immunofluorescence assay, and nucleic acid tests mainly include polymerase chain reaction (PCR), loop-mediated isothermal amplification (LAMP), reverse transcription polymerase spiral reaction, clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated proteins (Cas)-based assays. This review summarizes the progress of researches on serological and nucleic acid tests for detection of TBEV infections, so as to provide insights into prevention and control of tick-borne encephalitis.
