Mechanisms and research progress of circular RNAs in radon exposure-induced diseases
10.13491/j.issn.1004-714X.2025.02.027
- VernacularTitle:环状RNA在氡致相关疾病中的作用机制与研究进展
- Author:
Jia ZHANG
1
;
Xiaoliang LI
1
;
Jianlei RUAN
1
;
Jianxiang LIU
1
Author Information
1. Key Laboratary of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088 China.
- Publication Type:ReviewArticles
- Keywords:
Radon;
Biological effect;
Circular RNA;
Biomarker
- From:
Chinese Journal of Radiological Health
2025;34(2):303-308
- CountryChina
- Language:Chinese
-
Abstract:
Radon, the only naturally occurring radioactive noble gas, is among the most common radioactive nuclides to which humans are exposed. Radon can induce various biological effects in the human body and is a risk factor for lung cancer. Circular RNAs (circRNAs) are stable, tissue-specific, and abundantly expressed in body fluids. circRNAs can regulate gene expression and play an important role in the development of cancer. In this paper, we summarized the changes in the expression and function of circRNAs, highlighting the potential mechanisms of circRNAs in radon exposure-induced cancers. Our results provided theoretical support for the use of circRNAs as a biomarker of radon exposure-induced radiation damage, and offer a theoretical basis for the early diagnosis, treatment, and prevention of radon exposure-induced diseases.
