TCM Intervention in Prostate Cancer via Wnt/β-catenin Signaling Pathway： A Review
10.13422/j.cnki.syfjx.20241829
- VernacularTitle:中药调控Wnt/β-catenin信号通路干预前列腺癌的研究进展
- Author:
Lu LING
1
;
Jingyu XU
2
;
Junfei ZHAO
1
;
Songjiang LIU
2
Author Information
1. The First Clinical Medical College of Heilongjiang University of Chinese Medicine，Harbin 150000，China
2. The First Affiliated Hospital of Heilongjiang University of Chinese Medicine，Harbin 150000，China
- Publication Type:Journal Article
- Keywords:
prostate cancer;
Wnt/β-catenin signaling pathway;
traditional Chinese medicine;
research progress;
action mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(12):304-312
- CountryChina
- Language:Chinese
-
Abstract:
Prostate cancer is a malignant tumor that primarily arises from the epithelial tissue of the prostate in men. With the aggravation of population aging in China， the incidence rate of this disease has been continuously rising. Although the exact cause of prostate cancer remains unclear， it has been proven to be closely related to various factors， including individual genetic susceptibility， genetic mutations， dietary habits， and lifestyle. Research has shown that abnormal activation of the Wnt/β-catenin signaling pathway also plays an important role in the occurrence and development of prostate cancer. Multiple experimental results have revealed that traditional Chinese medicine （TCM）， with its multi-target and multi-stage mechanisms of action， exerts significant regulatory effects on key biological processes such as proliferation， migration， invasion， angiogenesis， and epithelial-mesenchymal transition （EMT） of prostate cancer cells. TCM has shown excellent potential in preventing prostate cancer progression and improving patient prognosis and has become a research focus in prostate cancer treatment in recent years. Based on this， this study reviewed the research on the regulation of the Wnt/β-catenin signaling pathway by TCM in the treatment of prostate cancer at home and abroad. It analyzed the mechanisms by which TCM intervention exerts anti-prostate cancer effects via this signaling pathway， identifying 29 different types of active ingredients in TCM， including alkaloids （e.g.， capsaicin， berberine）， flavonoids （e.g.， icariin and hyperoside）， polyphenols （e.g.， gastrodin and honokiol）， terpenes （e.g.， oridonin）， quinones （e.g.， aloe-emodin）， coumarins （e.g.， agrimonolide）， and saponins （e.g.， saikosaponin-d）. Additionally， one TCM medicinal substance （arsenic）， one drug pair （Danggui - Qieyi combination）， and two TCM formulae （Yishen Tonglong Tang and Guben Qingyuan Formula） were included. The study aims to deepen the understanding of the pathological mechanism of prostate cancer and to explore possible therapeutic targets， thereby providing new perspectives and approaches for clinical research and new drug development， and ultimately promoting the advancement and innovation of prostate cancer treatment strategies.
