ESCRT Mechanism-mediated Repair of Plasma Membrane Damage Induced by Regulatory Cell Death
10.16476/j.pibb.2024.0369
- VernacularTitle:ESCRT机制介导的调节性细胞死亡引起的质膜损伤修复及其机制
- Author:
Tian-Yang FENG
1
;
Le DENG
1
;
Gou XU
1
;
Li LI
1
;
Miao-Miao GUO
1
Author Information
1. College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing100048, China
- Publication Type:Journal Article
- Keywords:
ESCRT;
pyroptosis;
ferroptosis;
necroptosis;
plasma membrane repair
- From:
Progress in Biochemistry and Biophysics
2025;52(5):1099-1112
- CountryChina
- Language:English
-
Abstract:
The plasma membrane (PM) plays an essential role in maintaining cell homeostasis, therefore, timely and effective repair of damage caused by factors such as mechanical rupture, pore-forming toxins, or pore-forming proteins is crucial for cell survival. PM damage induces membrane rupture and stimulates an immune response. However, damage resulting from regulated cell death processes, including pyroptosis, ferroptosis, and necroptosis, cannot be repaired by simple sealing mechanisms and thus, requires specialized repair machinery. Recent research has identified a PM repair mechanism of regulated cell death-related injury, mediated by the endosomal sorting complexes required for transport (ESCRT) machinery. Here, we review recent progress in elucidating the ESCRT machinery-mediated repair mechanism of PM injury, with particular focus on processes related to regulated cell death. This overview, along with continued research in this field, may provide novel insights into therapeutic targets for diseases associated with dysregulation of regulated cell death pathways.
