Research progress of ocular surface damage in thyroid-associated ophthalmopathy
10.3980/j.issn.1672-5123.2025.6.13
- VernacularTitle:甲状腺相关眼病眼表损伤的研究进展
- Author:
Chengyu MA
1
;
Ying XIE
1
;
Zhijun DONG
1
Author Information
1. Graduate School of Chengde Medical University, Chengde 067000, Hebei Province, China; Department of Ophthalmology, Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei Province, China
- Publication Type:Journal Article
- Keywords:
thyroid-associated ophthalmopathy;
ocular surface damage;
inflammation;
research progress
- From:
International Eye Science
2025;25(6):942-945
- CountryChina
- Language:Chinese
-
Abstract:
Thyroid-associated ophthalmopathy(TAO), the most common orbital disease in adults, is characterized by a rising incidence globally. TAO typically presents with clinical features such as proptosis, upper eyelid retraction, ocular motility dysfunction, and diplopia. Additionally, it significantly compromises the integrity of ocular surface structures, leading to symptoms including dryness, foreign body sensation, photophobia and epiphora, which severely impair patients' visual function and quality of life. Recent studies have increasingly highlighted the roles of ocular surface inflammation, immune dysregulation and ocular surface exposure in the pathogenesis of TAO-related ocular surface damage. These factors collectively contribute to pathological changes in ocular surface structures, such as the conjunctiva, cornea, lacrimal gland and meibomian glands. This review comprehensively summarizes the latest research progress on ocular surface structural damage in TAO patients, aiming to provide a theoretical foundation and novel insights for the early diagnosis, disease evaluation and individualized treatment of TAO.
